Industry-Science Connections in Agriculture: Do public science collaborations and knowledge flows contribute to firm-level agricultural research productivity?

Prior research identifies a direct positive link between the stock of public scientific knowledge and agricultural productivity; however, an indirect contribution to agricultural productivity is also possible when this stock facilitates private sector invention. This study examines how “connectedness” between the stock of public scientific knowledge and private firms influences firm-level research productivity. Bibliographic information identifies the nature and degree to which firms use public agricultural science through citations and collaborations on scientific papers. Fixed effects models show that greater citations and collaborations with university researchers are associated with greater agricultural research productivity.public science, research productivity, patents, citations, collaboration, R&D, Productivity Analysis, Research and Development/Tech Change/Emerging Technologies, Q16, O31,

The AGN-starburst connection, Galactic superwinds, and M_BH - sigma

Recent observations of young galaxies at redshifts z ~ 3 have revealed simultaneous AGN and starburst activity, as well as galaxy-wide superwinds. I show that there is probably a close connection between these phenomena by extending an earlier treatment of the M_BH - sigma relation (King, 2003). As the black hole grows, an outflow drives a shell into the surrounding gas. This stalls after a dynamical time at a size determined by the hole's current mass and thereafter grows on the Salpeter timescale. The gas trapped inside this bubble cools and forms stars and is recycled as accretion and outflow. The consequent high metallicity agrees with that commonly observed in AGN accretion. Once the hole reaches a critical mass this region attains a size such that the gas can no longer cool efficiently. The resulting energy-driven flow expels the remaining gas as a superwind, fixing both the M_BH - sigma relation and the total stellar bulge mass at values in good agreement with observation. Black hole growth thus produces starbursts and ultimately a superwind.Comment: ApJ, in press, 4 page

Postcards from the Edge: A Review of the Business and Environment Literature

Environmental issues, while of growing interest, have been outside the main focus of business scholarship. This position on the periphery may have been a good thing. It allowed scholars of business and the environment to consider unusual theories and evaluate overlooked phenomenon. In doing so, they created a body of research that provides new insights on two topics of mainstream interest -- the sources of competitive advantage and the origin and function of self-regulatory institutions

Industry-science connections in agriculture : do public science collaborations and knowledge flows contribute to firm-level agricultural research productivity?

Prior research shows long-run productivity growth in agriculture is associated with increases in the stock of public scientific knowledge and private patented inventions. However, private inventions may be a function of the stock of public knowledge. In this paper, we examine the possibility that public knowledge contributes to productivity through its relationship with private sector invention. Our analysis identifies connections between the stock of public knowledge and private firm R&D and examines whether the degree of “connectedness” to public science is associated with greater firm-level research productivity in agriculture. Bibliographic information identifies the nature and degree to which firms use public agricultural science through citations and collaborations on scientific papers. Fixed effects models show that greater citations and collaborations with university researchers are associated with greater private agricultural research productivity

Role of angiopoietin-like protein 3 in sugar-induced dyslipidemia in rhesus macaques: suppression by fish oil or RNAi.

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects of a high-sugar (high-fructose) diet on circulating ANGPTL3 concentrations in rhesus macaques. Plasma ANGPTL3 concentrations increased ∼30% to 40% after 1 and 3 months of a high-fructose diet (both P < 0.001 vs. baseline). During fructose-induced metabolic dysregulation, plasma ANGPTL3 concentrations were positively correlated with circulating indices of insulin resistance [assessed with fasting insulin and the homeostatic model assessment of insulin resistance (HOMA-IR)], hypertriglyceridemia, adiposity (assessed as leptin), and systemic inflammation [C-reactive peptide (CRP)] and negatively correlated with plasma levels of the insulin-sensitizing hormone adropin. Multiple regression analyses identified a strong association between circulating APOC3 and ANGPTL3 concentrations. Higher baseline plasma levels of both ANGPTL3 and APOC3 were associated with an increased risk for fructose-induced insulin resistance. Fish oil previously shown to prevent insulin resistance and hypertriglyceridemia in this model prevented increases of ANGPTL3 without affecting systemic inflammation (increased plasma CRP and interleukin-6 concentrations). ANGPTL3 RNAi lowered plasma concentrations of ANGPTL3, triglycerides (TGs), VLDL-C, APOC3, and APOE. These decreases were consistent with a reduced risk of atherosclerosis. In summary, dietary sugar-induced increases of circulating ANGPTL3 concentrations after metabolic dysregulation correlated positively with leptin levels, HOMA-IR, and dyslipidemia. Targeting ANGPTL3 expression with RNAi inhibited dyslipidemia by lowering plasma TGs, VLDL-C, APOC3, and APOE levels in rhesus macaques

Industry-science connections in agriculture: Do public science collaborations and knowledge flows contribute to firm-level agricultural research productivity?

Prior research shows long-run productivity growth in agriculture is associated with increases in the stock of public scientific knowledge and private patented inventions. However, private inventions may be a function of the stock of public knowledge. In this paper, we examine the possibility that public knowledge contributes to productivity through its relationship with private sector invention. Our analysis identifies connections between the stock of public knowledge and private firm R&D and examines whether the degree of 'connectedness' to public science is associated with greater firm-level research productivity in agriculture. Bibliographic information identifies the nature and degree to which firms use public agricultural science through citations and collaborations on scientific papers. Fixed effects models show that greater citations and collaborations with university researchers are associated with greater private agricultural research productivity. --Public science,research productivity,patents,citations,collaboration,R&D,bibliometrics

The MIDdleware Assurance Substrate: Enabling Strong Real-Time Guarantees in Open Systems With OpenFlow

Middleware designed for use in Distributed Real-Time and Embedded (DRE) systems enable cost and development time reductions by providing simple communications abstractions and hiding operating system-level networking API details from developers. While current middleware technologies can hide many low-level details, designers must provide a static configuration for the system’s underlying network in order to achieve required performance characteristics. This has not been a problem for many types of DRE systems where the configuration of the system is relatively fixed from the factory (e.g., aircraft or naval vessels). However for truly open systems (i.e., systems where end users can add or subtract components at runtime) the standard static network configuration approach cannot guarantee that required performance will be met because network resource demands are not fully known a priori. Open systems with stringent performance requirements need middleware that can dynamically manage the underlying network configuration automatically in response to changing demands. Fortunately, recent trends in networking have resulted in a wide variety of networking equipment that expose a standardized low-level interface to their configuration via the OpenFlow protocol. In this paper we discuss how OpenFlow can be leveraged by DRE middleware to automatically provide performance guarantees. In order to make the discussion concrete, we describe the architecture of our prototype middleware MIDAS as well as the details of one example network resource management strategy. We demonstrate the feasibility of our approach via performance assesment of a simple DRE application using our MIDAS and commerically available OpenFlow hardware

Electron correlation in Li+, He, H− and the critical nuclear charge system ZC: energies, densities and Coulomb holes

This paper presents high accuracy correlation energies, intracule densities and Coulomb hole(s) for the lithium cation, helium, hydride ion and the system with the critical nuclear charge, Z_C, for binding two electrons. The fully-correlated (FC) wavefunction and the Hartree-Fock (HF) wavefunction are both determined using a Laguerre-based wavefunction. It is found that for the lithium cation and the helium atom a secondary Coulomb hole is present, in agreement with a previous literature finding, confirming a counter-intuitive conclusion that electron correlation can act to bring distant electrons closer together. However, no evidence for a tertiary Coulomb hole is found. For the hydride anion and the system just prior to electron detachment only a single Coulomb hole is present and electron correlation decreases the probability of finding the electrons closer together at all radial distances. The emergence of a secondary Coulomb hole is investigated and found to occur between Z =1.15 and 1.20. The FC and HF energies and intracule densities (in atomic units) used to calculate the correlation energy and Coulomb hole respectively, are accurate to at least the nano-scale for helium and the cation and at least the micro-scale for the anions

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown. We hypothesized that the transcriptional regulator of the stress response, heat shock factor 1 (HSF1), would play an important role in prion disease. Uninoculated HSF1 knockout (KO) mice used in our study do not show signs of neurodegeneration as assessed by survival, motor performance, or histopathology. When inoculated with Rocky Mountain Laboratory (RML) prions HSF1 KO mice had a dramatically shortened lifespan, succumbing to disease ≈20% faster than controls. Surprisingly, both the onset of home-cage behavioral symptoms and pathological alterations occurred at a similar time in HSF1 KO and control mice. The accumulation of proteinase K (PK)-resistant PrP also occurred with similar kinetics and prion infectivity accrued at an equal or slower rate. Thus, HSF1 provides an important protective function that is specifically manifest after the onset of behavioral symptoms of prion disease

What’s Behind Recent Transit Ridership Trends in the Bay Area? Volume I: Overview and Analysis of Underlying Factors

Public transit ridership has been falling nationally and in California since 2014. The San Francisco Bay Area, with the state’s highest rates of transit use, had until recently resisted those trends, especially compared to Greater Los Angeles. However, in 2017 and 2018 the region lost over five percent (>27 million) of its annual riders, despite a booming economy and service increases. This report examines Bay Area transit ridership to understand the dimensions of changing transit use, its possible causes, and potential solutions. We find that: 1) the steepest ridership losses have come on buses, at off-peak times, on weekends, in non-commute directions, on outlying lines, and on operators that do not serve the region’s core employment clusters; 2) transit trips in the region are increasingly commute-focused, particularly into and out of downtown San Francisco; 3) transit commuters are increasingly non-traditional transit users, such as those with higher incomes and automobile access; 4) the growing job-housing imbalance in the Bay Area is related to rising housing costs and likely depressing transit ridership as more residents live less transit-friendly parts of the region; and 5) ridehail is substituting for some transit trips, particularly in the off-peak. Arresting falling transit use will likely require action both by transit operators (to address peak capacity constraints; improve off-peak service; ease fare payments; adopt fare structures that attract off-peak riders; and better integrate transit with new mobility options) and public policymakers in other realms (to better meter and manage private vehicle use and to increase the supply and affordability of housing near job centers)